What is the Role of Nucleobase Analogs in Toxicology?
Nucleobase analogs are compounds that mimic the structure of natural nucleobases but harbor subtle differences that can disrupt normal DNA and RNA functions. These analogs are used in therapeutic settings, such as antiviral and anticancer drugs, where they can interfere with the replication of rapidly dividing cells. However, because they integrate into genetic material, they may also lead to unintended toxic effects, including off-target mutations and toxicity to non-cancerous cells.
