What is the Role of Oxidative Stress in Cardiotoxicity?
Oxidative stress plays a significant role in cardiotoxicity. It occurs when there is an imbalance between reactive oxygen species (ROS) production and the antioxidant defenses of the cell. High levels of ROS can damage cellular components, including lipids, proteins, and DNA, leading to cell death or dysfunction. Cardiac cells are particularly vulnerable because of their high oxygen demand and limited regenerative capacity.
