In toxicology, lipid peroxidation is considered a key mechanism of cellular injury induced by toxicants. Many xenobiotics, including drugs, environmental pollutants, and industrial chemicals, can generate ROS, leading to oxidative stress and peroxidation. This is particularly relevant in the context of liver toxicity, where lipid peroxidation is a major pathway of hepatocyte damage. Monitoring biomarkers of peroxidation, such as MDA and HNE, is crucial in assessing the oxidative damage and toxicity potential of compounds.
