glutathione s transferases

How Do GSTs Function in Detoxification?

GSTs facilitate the detoxification process by binding to the electrophilic sites of toxic compounds and transferring the GSH moiety. This process neutralizes the toxic potential of the compounds, thereby preventing cellular damage. The enzyme activity of GSTs is crucial in protecting cells from oxidative stress and chemical-induced damage. Moreover, by enhancing the solubility of toxins, GSTs ensure their efficient removal through renal and biliary excretion.

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