The mainstay of treatment is discontinuation of the offending agent(s) and supportive care. Mild cases often resolve with withdrawal of the serotonergic drug and symptomatic treatment. Severe cases may require hospitalization and intensive care. Medications such as benzodiazepines can be used to control agitation and muscle rigidity, while cyproheptadine, a serotonin antagonist, may be administered in severe cases.
