What Methods are Used in Reproductive Toxicity Testing?
Several methods are employed in reproductive toxicity testing, ranging from in vivo animal studies to in vitro assays. In vivo studies typically involve rodents and assess endpoints such as mating behavior, fertility rates, and offspring development. In vitro methods use cell cultures to evaluate the effects of substances on reproductive cells and tissues, offering a more ethical and cost-effective alternative to animal testing. Computational models are also increasingly used to predict reproductive toxicity based on chemical structure and biological data.
