What Role do Amyloid Plaques Play in Alzheimer's Disease?
In the context of Alzheimer's disease, amyloid plaques are a hallmark pathology. They are found in the brains of patients and are closely linked to the progression of the disease. The amyloid cascade hypothesis posits that the accumulation of amyloid-beta peptides and the subsequent plaque formation are initial events that lead to tau pathology, synaptic dysfunction, and neuronal loss.
