The dose-response relationship is a fundamental concept in toxicology. With subtle and cumulative effects, even low doses can be harmful if exposure is sustained over a long duration. The body's detoxification systems, including the liver and kidneys, work to eliminate toxins, but prolonged exposure can impair these systems, leading to accumulation of the toxicant. Therefore, both the dose and the duration of exposure are critical factors in determining the risk of subtle and cumulative effects.
