What Role Do Enzymes Play in Biochemical Toxicology?
Enzymes play a critical role in the metabolism of toxicants. Cytochrome P450 enzymes, for instance, are involved in the oxidative metabolism of many xenobiotics. These enzymes can convert lipophilic compounds into more hydrophilic metabolites, facilitating their excretion. However, some enzymatic reactions can also activate non-toxic compounds into reactive intermediates that are harmful.
