What Role Do Heterodimers Play in Endocrine Disruption?
Endocrine disruptors are chemicals that interfere with hormonal systems, and heterodimers are involved in the signaling pathways of various hormones. For instance, the aryl hydrocarbon receptor (AhR) forms a heterodimer with the aryl hydrocarbon receptor nuclear translocator (ARNT) to modulate gene expression. Disruption of such heterodimeric complexes by toxicants can lead to adverse effects on reproductive and developmental health, emphasizing the need to study these interactions in endocrine disruption research.
