What Role Does Adenylyl Cyclase Play in Drug Toxicity?
Drugs that influence cAMP levels can have toxicological consequences by altering adenylyl cyclase activity. For instance, beta-adrenergic agonists activate adenylyl cyclase through GPCRs, increasing cAMP levels. Excessive activation can lead to cardiovascular toxicity, manifesting as arrhythmias or hypertension. Conversely, the inhibition of adenylyl cyclase can lead to reduced cAMP, impacting heart rate and blood pressure, and may contribute to drug toxicity.
