What Role Does Stereochemistry Play in Metabolism?
Stereochemistry can influence how a compound is metabolized in the body. The enzymes responsible for metabolism often exhibit stereoselectivity, meaning they preferentially metabolize one enantiomer over another. This can result in differing half-lives, clearance rates, and bioavailability between enantiomers. Consequently, the stereochemical composition of a compound can affect its overall toxicity profile.
