Ensuring the safety of intradermal administration involves several key measures. Proper technique is critical to avoid complications such as infection or tissue damage. Additionally, the choice of needle size, depth of injection, and the volume of the substance must be carefully controlled. Monitoring for local and systemic reactions after administration is essential to identify any immediate or delayed adverse effects. Finally, understanding the toxicokinetics and toxicodynamics of the substance is vital to predict and mitigate potential toxicological risks.