Which Inflammasomes are Most Relevant in Toxicology?
There are several types of inflammasomes, but the most studied in toxicology include the NLRP3 inflammasome, the AIM2 inflammasome, and the NLRC4 inflammasome. The NLRP3 inflammasome is particularly significant due to its role in responding to a wide array of signals, including crystalline substances like silica and asbestos, which are known to cause inflammation and fibrosis. Understanding the specific inflammasomes activated by different toxicants helps in developing targeted therapeutic interventions.
