While lipoic acid is safe for most people, certain individuals should exercise caution. Those with a history of thiamine deficiency, such as chronic alcoholics, should avoid high doses of lipoic acid, as it may exacerbate this condition. Additionally, people with thyroid disorders should be cautious, as lipoic acid may interact with thyroid hormone levels. Pregnant and lactating women should consult a healthcare provider before use, as safety in these populations has not been thoroughly established.
