Certain populations, such as children, the elderly, pregnant women, and individuals with pre-existing health conditions, are more vulnerable to toxic exposures. For example, children's metabolic rates and developmental stages make them more sensitive to toxins. The elderly may have compromised detoxification systems, and pregnant women have considerations for the developing fetus. Genetic factors can also play a significant role in determining vulnerability, with some individuals having genetic polymorphisms that affect metabolism and detoxification pathways.