Certain body sites are more susceptible to toxicants due to their physiological functions and chemical properties. For instance, the liver is a major site for the metabolism of toxicants, making it particularly vulnerable to hepatic toxicity. The kidneys, responsible for filtering blood and excreting waste, are another critical site that can be affected by nephrotoxic substances. Understanding which body sites a toxicant targets helps in diagnosing and treating toxicity more effectively.