What Role do CYP450 Enzymes Play in Drug Development?
CYP450 enzymes are a critical consideration in drug development and safety assessment. Early in the drug development process, potential drug candidates are screened for their ability to inhibit or induce CYP450 enzymes. This helps identify possible drug-drug interactions and toxicity issues before clinical trials. Additionally, understanding the metabolic pathways mediated by CYP450 enzymes aids in predicting the pharmacokinetics and dynamics of new drugs, facilitating the design of safer and more effective therapeutic agents.
