Solubility is a critical factor that influences a chemical's absorption, distribution, metabolism, and excretion (ADME) in the body. Water-soluble compounds often have different toxicokinetic profiles compared to lipid-soluble ones. Water-soluble chemicals are usually excreted more rapidly, while lipid-soluble chemicals tend to accumulate in fatty tissues, potentially leading to chronic toxicity. Understanding solubility helps toxicologists predict how a substance will behave once it enters an organism.
