Can Genetic Variations Affect the Vitamin K Cycle?
Yes, genetic variations can impact the efficiency of the vitamin K cycle. Polymorphisms in the VKORC1 gene, which encodes the VKOR enzyme, can influence an individual's sensitivity to anticoagulant rodenticides. These genetic differences can lead to variations in the required dosage of vitamin K antagonists for effective anticoagulation, highlighting the need for personalized medicine in managing patients exposed to such toxicants.
