In the field of toxicology, TFIIH is significant because it is involved in the cell's response to DNA-damaging agents. Many toxic substances, such as carcinogens and radiation, cause DNA damage. TFIIH helps in the nucleotide excision repair (NER) pathway, which is crucial for correcting these DNA lesions. Understanding how TFIIH functions can help in assessing the toxicological impact of various substances and the potential for causing mutations or cancer.
