Dysfunction in TFIIH can lead to severe consequences, including increased susceptibility to cancers and genetic disorders. For instance, mutations in TFIIH subunits are linked to diseases like Xeroderma Pigmentosum and Cockayne Syndrome, which are characterized by heightened sensitivity to UV radiation and defects in DNA repair mechanisms. Understanding these dysfunctions is crucial for developing targeted therapies and mitigating the risks associated with exposure to toxic agents.
