Why is the Partition Coefficient Important in Toxicology?
In toxicology, the partition coefficient is essential for predicting the absorption, distribution, metabolism, and excretion (ADME) of chemicals. It helps in determining the bioavailability and potential toxicity of compounds. A high Kow indicates that a compound is lipophilic, meaning it is likely to accumulate in fatty tissues, whereas a low Kow suggests that a compound is hydrophilic and more likely to be excreted in urine.
