Generally, natural sweeteners are considered safe for consumption when used in moderation. However, the safety of these sweeteners can depend on processing methods, individual health conditions, and consumption levels. For instance, while stevia is considered safe for most people, it may cause side effects such as bloating or nausea in some individuals. Toxicology studies have shown that high doses of certain sweeteners can lead to health issues, although these doses are typically much higher than what one would consume through a regular diet.