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What Are the Challenges in Detecting and Diagnosing Prion Diseases?


Diagnosing prion diseases is particularly challenging due to their long incubation periods and the similarity of symptoms to other neurodegenerative disorders. Currently, definitive diagnosis often requires brain biopsy or autopsy. Recent advances in diagnostic techniques, such as the development of real-time quaking-induced conversion (RT-QuIC), offer promise for early detection. However, the lack of routine diagnostic tests remains a significant hurdle in managing these diseases.

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