Are there any toxicological concerns with PDE interactions?
Yes, potential toxicological concerns arise from drug-drug interactions involving PDEs. For example, combining PDE inhibitors with other medications that elevate cAMP or cGMP levels can lead to synergistic effects, increasing the risk of side effects. Additionally, certain environmental toxins and pollutants may interfere with PDE activity, potentially exacerbating their toxic effects. Therefore, assessing the interactions between PDEs and various compounds is crucial in toxicological evaluations.
