Are There Challenges in Targeting TRAIL Receptors?
Although TRAIL receptor targeting is promising, several challenges remain. Resistance to TRAIL-induced apoptosis can occur due to various factors, such as upregulation of anti-apoptotic proteins, mutations in TRAIL receptors, or overexpression of decoy receptors. Understanding these resistance mechanisms is crucial for improving the efficacy of TRAIL-based therapies and overcoming limitations in clinical applications.
