Can Genetic Polymorphisms in ABC Transporters Influence Toxicity?
Yes, genetic polymorphisms in ABC transporter genes can significantly influence an individual's response to drugs and toxicants. Variations in these genes may alter the transporters' expression or function, leading to differences in toxicokinetics. Such polymorphisms can affect drug efficacy and toxicity, making it essential to consider genetic factors when evaluating treatment outcomes or exposure risks.
