Given its role in apoptosis, the apoptosome represents a promising target for therapeutic intervention. In cancer therapy, strategies to enhance apoptosome activity could help induce apoptosis in resistant cancer cells. Conversely, in diseases where excessive apoptosis is a problem, inhibiting apoptosome formation might protect against unnecessary cell loss. Researchers are exploring small molecules and other agents that can modulate apoptosome activity, offering hope for new treatments that can effectively manage diseases linked to apoptotic dysregulation.