Aberrations in apoptosome function are implicated in a variety of diseases. In cancer, for example, defective apoptosome activity can lead to the survival of cells that would otherwise undergo apoptosis, contributing to uncontrolled cell proliferation. Conversely, excessive apoptosome activity can contribute to diseases characterized by excessive cell death, such as Alzheimer's disease and Parkinson's disease. Thus, the apoptosome serves as a potential therapeutic target in these conditions, where modulating its activity could restore normal apoptotic processes.
