How Can TP53 Status Influence Treatment Strategies?
The status of TP53 can significantly influence the choice and efficacy of cancer treatments. Tumors with wild-type TP53 are generally more responsive to chemotherapy and radiation therapy, as these treatments often rely on inducing DNA damage that activates p53-mediated apoptosis. Conversely, tumors harboring TP53 mutations may be resistant to conventional therapies, necessitating alternative strategies such as the use of MDM2 inhibitors or reactivating mutant p53 to restore its tumor suppressor functions.
