What is the Role of TP53 in Cellular Stress Response?
TP53 is activated in response to a wide range of genotoxic stressors, such as radiation, ultraviolet light, and chemical mutagens. Upon activation, p53 can induce cell cycle arrest, allowing time for DNA repair mechanisms to correct damage. If the damage is irreparable, p53 can initiate apoptosis to prevent the propagation of damaged cells. This dual role is critical in maintaining cellular and organismal health by preventing the accumulation of mutations that could lead to cancer.
