What is the Relationship Between TP53 and Carcinogens?
Carcinogens can cause DNA damage that may lead to mutations in the TP53 gene. The loss of functional p53 allows cells with damaged DNA to evade apoptosis and continue to divide, increasing the likelihood of developing cancer. Studies have shown that exposure to certain chemicals, such as benzene and polycyclic aromatic hydrocarbons, is associated with specific TP53 mutations in tumors, highlighting its role as a biomarker for carcinogenic exposure.
