How Does TP53 Mutation Affect Toxicological Outcomes?
Mutations in the TP53 gene are among the most common alterations in human cancers. These mutations can lead to the loss of normal p53 function, resulting in impaired DNA damage response and increased susceptibility to carcinogenesis. In toxicology, understanding the mutational status of TP53 can inform the risk assessment of chemical exposures, as individuals with mutant TP53 may be more susceptible to the carcinogenic effects of environmental toxins.
