How Do Anticoagulant Rodenticides Affect the Vitamin K Cycle?
Anticoagulant rodenticides work by disrupting the vitamin K cycle. They inhibit the VKOR enzyme, preventing the conversion of vitamin K epoxide back to its active form, vitamin K hydroquinone. This inhibition results in the depletion of active vitamin K, leading to a deficiency in carboxylated clotting factors and increased risk of bleeding.
