Hypnotics can interact with a variety of other drugs, often leading to enhanced sedative effects or increased risk of toxicity. Co-administration with other CNS depressants, such as alcohol, opioids, or antihistamines, can potentiate sedation and respiratory depression. Additionally, some hypnotics are metabolized by the cytochrome P450 enzyme system, and drugs that inhibit or induce these enzymes can alter hypnotic drug levels, leading to either increased toxicity or decreased efficacy.
