How does RAD51 interact with other DNA repair proteins?
RAD51 functions in concert with several other proteins involved in DNA repair. BRCA2 is a key partner, facilitating RAD51's loading onto DNA strands. Other proteins, such as RAD52, RAD54, and the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3), assist in various stages of homologous recombination. Disruptions in the interactions between RAD51 and these proteins can compromise DNA repair efficiency, leading to increased sensitivity to DNA-damaging agents.
