How Do Mitochondrial Mutations Affect Cellular Function?
Mitochondrial mutations can lead to a range of cellular dysfunctions. One major consequence is impaired energy production, as mutations can affect the electron transport chain, leading to decreased ATP generation. This energy deficit can impair various cellular processes and contribute to cell death. Moreover, dysfunctional mitochondria can produce excessive ROS, leading to oxidative stress and further damage not only to mtDNA but also to proteins and lipids within the cell.
