oxidation and reduction

How Do Redox Reactions Influence Drug Metabolism?

Redox reactions significantly impact drug metabolism, influencing both therapeutic efficacy and toxicity. Phase I metabolic reactions, primarily oxidation, are often the first step in drug metabolism, introducing functional groups to enhance solubility. Phase II reactions, which include conjugation, further increase solubility for excretion. Some drugs require metabolic activation via oxidation to become pharmacologically active, while others may produce toxic metabolites necessitating careful monitoring and dose adjustment.

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