How Do Toxicologists Address Uncertainty in Extrapolation?
Toxicologists employ several strategies to address uncertainties in extrapolation:
Safety Factors: To account for uncertainties, toxicologists use safety or uncertainty factors, which provide a margin of safety in risk assessments. Use of Conservative Assumptions: When data is uncertain, toxicologists often adopt conservative assumptions to protect human health and the environment. Validation with Human Data: Whenever possible, extrapolated predictions are validated or adjusted based on available human data. Advanced Computational Models: The use of computational toxicology and mathematical modeling can enhance the accuracy of extrapolation.
