There are several types of extrapolation commonly used in toxicology:
Inter-species Extrapolation: This involves predicting toxic effects in humans based on data obtained from animal studies. Various models and scaling factors are applied to account for physiological differences between species. Intra-species Extrapolation: This type considers variations within a species, such as differences in susceptibility among populations or individuals, often using safety factors. Low-dose Extrapolation: Often used to estimate the risk at low exposure levels based on high-dose experimental data, which is particularly relevant for risk assessment. Temporal Extrapolation: This involves extending data from short-term studies to predict long-term effects.
