How are Phospholipids Involved in Cellular Signaling and Toxicity?
Phospholipids play a significant role in cellular signaling, which can be affected by toxicants. Phosphatidylinositol, a type of phospholipid, is critical in signal transduction pathways. Toxicants can disrupt these pathways by altering phospholipid metabolism, leading to impaired cellular responses and increased susceptibility to damage. Furthermore, toxicants can activate phospholipase enzymes, leading to the release of signaling molecules like arachidonic acid, which can exacerbate inflammatory responses.
