How do toxins affect ADP-ribosyltransferase activity?
Certain toxins can directly modulate the activity of ADP-ribosyltransferases, either by inhibiting or activating these enzymes. For example, the bacterial toxin diphtheria toxin and cholera toxin exert their effects by modifying host cell proteins through ADP-ribosylation. Such interactions can disrupt cellular processes and lead to disease. Conversely, some chemicals can inhibit PARP activity, thereby affecting DNA repair and cell survival. Investigating how different toxins influence ADP-ribosyltransferase activity can provide insights into their mechanisms of toxicity and help identify potential therapeutic interventions.
