ADP-ribosyltransferases are a family of enzymes that catalyze the transfer of ADP-ribose units from NAD+ to target proteins. This ADP-ribosylation modifies the function of proteins and can affect various cellular processes, such as DNA repair, transcription, and cellular signaling. There are two main types of ADP-ribosyltransferases: PARPs (Poly [ADP-ribose] polymerases) and mono-ADP-ribosyltransferases. These enzymes are crucial for maintaining cellular homeostasis, especially under stress conditions induced by toxic agents.
