How does Cremophor EL cause hypersensitivity reactions?
Hypersensitivity reactions to Cremophor EL are typically characterized by histamine release, leading to symptoms such as flushing, rash, difficulty breathing, and hypotension. These reactions can range from mild to severe and are believed to result from Cremophor ELâs interaction with mast cells and basophils, which triggers histamine release. Pre-treatment with antihistamines and corticosteroids is often employed to mitigate these reactions in sensitive patients.
