What are the toxicological concerns associated with Cremophor EL?
Cremophor EL can induce a range of adverse effects, primarily due to its interaction with biological membranes and proteins. The most concerning toxicological issues include hypersensitivity reactions, anaphylaxis, and effects on the cardiovascular and nervous systems. The surfactant can alter membrane fluidity, disrupt cellular functions, and lead to the release of histamine, triggering allergic responses.
