What are the cardiovascular effects of Cremophor EL?
In some cases, Cremophor EL can affect the cardiovascular system, causing changes in blood pressure and heart rate. This is particularly pertinent in formulations administered intravenously at high concentrations. The surfactantâs impact on vascular permeability and its potential to cause vasodilation are key factors contributing to these effects. Monitoring cardiovascular parameters during administration is crucial to managing any adverse outcomes.
