How Does CYP2E1 Contribute to Disease Pathogenesis?
CYP2E1 is implicated in the pathogenesis of several diseases, particularly those involving the liver. Its role in the metabolic activation of hepatotoxic compounds makes it a key player in alcohol-induced liver injury. The enzyme's contribution to oxidative stress and inflammation further exacerbates tissue damage. Additionally, CYP2E1's involvement in the bioactivation of carcinogens links it to cancer development, particularly in organs with high enzyme expression.
