How Does Genetic Variability Affect CYP3A5 Function?
The CYP3A5 gene exhibits genetic polymorphisms that result in varying levels of enzyme activity among individuals. Some people express CYP3A5 at high levels, while others have little to no expression. This genetic variability can influence the metabolism of drugs such as tacrolimus, used in organ transplantation. People with active CYP3A5 may require higher doses of certain medications to achieve therapeutic effects, whereas those with inactive versions may experience increased toxicity.
