What are the Clinical Implications of CYP3A5 Variability?
Clinically, understanding CYP3A5 variability is important for personalized medicine. Tailoring drug therapy based on individual CYP3A5 expression can optimize treatment efficacy and minimize adverse effects. For example, genotyping patients for CYP3A5 can guide dosing strategies for drugs like tacrolimus, ensuring proper immunosuppression while avoiding toxicity. This approach can improve outcomes in transplant recipients and other patient populations.
